Invitrogen™ Phospho-Tau-F (Thr231) Recombinant Rabbit Monoclonal Antibody (SC58-08)

Rabbit Recombinant Monoclonal Antibody

Supplier:  Invitrogen™ MA545027

Catalog No. PIMA545027

Description

Phospho-Tau-F (Thr231) Recombinant Monoclonal Antibody for Western Blot, ICC/IF, IHC (F), IHC (P), IP

Tau, also known as MAPT (microtubule-associated protein tau), MAPTL, MTBT1 or TAU, is a 758 amino acid protein that localizes to the cytoplasm, as well as to the cytoskeleton and the cell membrane, and contains four Tau/MAP repeats. Expressed in neuronal tissue and existing as multiple alternatively spliced isoforms, Tau functions to promote microtubule assembly and stability and is thought to be involved in the maintenance of neuronal polarity. Tau may also link microtubules with neural plasma membrane components and, addition to its role in microtubule stability, is also necessary for cytoskeletal plasticity. Tau is highly subject to a variety of post-translational modifications, including phosphorylation on serine and threonine residues, polyubiquitination (and subsequent proteasomal degradation) and glycation of specific Tau isoforms. Defects in the gene encoding Tau are associated with Alzheimers disease, pallido-ponto-nigral degeneration (PPND), corticobasal degeneration (CBD) and progressive supranuclear palsy (PSP).

Specifications

• Antigen: Phospho-Tau-F (Thr231)
• Classification: Recombinant Monoclonal
• Concentration: 1 mg/mL
• Formulation: TBS with 0.05% BSA, 40% glycerol and 0.05% sodium azide; pH 7.4
• Gene Accession No.: P10636, P10637, P19332
• Gene Symbols: MAPT
• Immunogen: Synthetic phospho-peptide corresponding to residues surrounding Thr231 of human Tau-F.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

• Applications: Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry
• Clone: SC58-08
• Conjugate: Unconjugated
• Gene: MAPT
• Gene Alias: 2N4R; Tau-4
• Host Species: Rabbit
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 17762, 29477, 4137
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov