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Phospho-Tau protein (Thr212) Rabbit anti-Human, Polyclonal, Bioss Non-distribution product as customer accommodation.

Rabbit Polyclonal Antibody

Manufacturer:  BiossSupplier Diversity Partner BS5419R

Catalog No. 50-198-6550


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Description

Description

Tau is a neuronal microtubule-associated protein found predominantly on axons. The function of Tau is to promote tubulin polymerization and stabilize microtubules. The C-terminus binds axonal microtubules while the N- terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton while the longer isoforms may preferentially play a role in its stabilization. In its hyper-phosphorylated form, Tau is the major component of paired helical filaments (PHF), the building block of neurofibrillary lesions in Alzheimer ft.s diseases (AD) brain. Hyper-phosphorylation impairs the microtubule binding function of Tau, resulting in the destabilization of microtubules in AD brains, ultimately leading to the degeneration of the affected neurons. Numerous serine/threonine kinases phosphorylate Tau, including GSK-3beta, protein kinase A (PKA), cyclin-dependent kinase 5 (cdk5) and casein kinase II. Hyper-phosphorylated Tau is found in neurofibrillary lesions in a range and other central nervous system disorders such as Pick ft.s disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy.
Specifications

Specifications

Phospho-Tau protein (Thr212)
Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Unconjugated
MAPT
Liquid
Rabbit
IgG
100 μL
-20°C
Primary
4137
MAPT
1 μg/mL
PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
P10636
AI413597; AW045860; BOS_19251; DDPAC; FLJ31424; FTDP17; FTDP-17; G protein beta1/gamma2 subunit-interacting factor 1; Mapt; MAPTL; MGC138549; microtubule associated protein tau; Microtubule-associated protein tau; microtubule-associated protein tau, isoform 4; MSTD; Mtapt; MTBT1; MTBT2; Neurofibrillary tangle protein; Neuronal Marker; Paired helical filament-tau; PHFtau; PHF-tau; PPND; PPP1R103; protein phosphatase 1, regulatory subunit 103; pTau; RNPTAU; Tau; Tau microtubule-associated protein; Tau-4; Tau5
KLH conjugated synthetic phosphopeptide derived from human MAPT isoform 2 around the phosphorylation site of Thr212 [SR (p-T)PS].
Protein A
RUO
Antibody
Polyclonal
Human
SDS
Documents
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