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Invitrogen™ Phospho-TEK (Tyr1102) Polyclonal Antibody
Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA538394
Description
Phospho-TEK (Tyr1102) Polyclonal Antibody for IHC (P), pep-ELISA
The TEK receptor tyrosine kinase is expressed almost exclusively in endothelial cells. TEK signaling appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis, and defects in TEK are associated with inherited venous malformations. The ligand angiopoietin-1 binds to this receptor and mediates a signaling pathway that functions in embryonic vascular development. Immunoblotting showed that TIE2 expression was increased by thyroid-stimulating hormone and agents that increased intracellular cAMP. HSCs expressing the receptor tyrosine kinase TIE2 are quiescent and antiapoptotic and comprise a side population of HSCs that adhere to osteoblasts in the bone marrow niche.
Specifications
Phospho-TEK (Tyr1102) | |
Polyclonal | |
Unconjugated | |
TEK | |
AA517024; Angiopoietin-1 receptor; CD202B; CD202b antigen; EC 2.7.10; EC 2.7.10.1; Endothelial tyrosine kinase; endothelial-specific receptor tyrosine kinase; endothelium-specific receptor tyrosine kinase 2; endothelium-specific receptor tyrosine kinase Tie-2; hTIE2; Hyk; mTIE2; p140 TEK; protein-tyrosine kinase Tie2; STK1; Tek; TEK receptor tyrosine kinase; TEK tyrosine kinase, endothelial; TEKT1; Tektin-1; Tie2; tie-2; tunica interna endothelial cell kinase; Tyrosine kinase with Ig and EGF homology domains-2; tyrosine kinases that contain immunoglobulin-like loops and epidermal growth factor-similar domains 2; tyrosine-protein kinase receptor TEK; Tyrosine-protein kinase receptor Tie-2; VMCM; VMCM1 | |
Rabbit | |
Antigen Affinity Chromatography | |
RUO | |
21687, 7010 | |
-20°C | |
Liquid |
Immunohistochemistry (Paraffin), Peptide ELISA | |
1 mg/mL | |
Dulbecco's PBS with 50% glycerol and 0.02% sodium azide; pH 7.4 | |
Q02763, Q02858 | |
TEK | |
A synthetic phosphopeptide derived from human TIE2 around the phosphorylation site of Tyr1102 (K-T-YP-V-N). | |
100 μg | |
Primary | |
Human, Mouse | |
Antibody | |
IgG |
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