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Phospho-TERT (Ser1125) Rabbit anti-Human, Polyclonal, Bioss
SDP

Catalog No. 501986676
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50-198-6676 100 μL
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Catalog No. 50-198-6676 Supplier Bioss Supplier No. BS5605R
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Description

Rabbit Polyclonal Antibody

Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase (TERT) have been identified; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity.

Specifications

Antigen Phospho-TERT (Ser1125)
Applications Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 μg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene TERT
Gene Accession No. O14746
Gene Alias CMM9; DKCA2; DKCB4; EST2; HEST2; hTERT; hTRT; PFBMFT1; RGD:70494}; TCS1; Telomerase catalytic subunit; Telomerase reverse transcriptase; telomerase reverse transcriptase beta; Telomerase-associated protein 2; TERT; tert {ECO:0000312; TP2; TR; TRT
Gene Symbols TERT
Host Species Rabbit
Immunogen KLH conjugated synthetic phosphopeptide derived from human TERT around the phosphorylation site of Ser1125.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 7015
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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