Invitrogen™ Phospho-TERT (Ser227) Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA538817

Catalog No. PIPA538817

Description

Phospho-TERT (Ser227) Polyclonal Antibody for ICC/IF, pep-ELISA

Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase (TERT) have been identified; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity.

Specifications

• Antigen: Phospho-TERT (Ser227)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TERT
• Gene Alias: CMM9; DKCA2; DKCB4; EST2; HEST2; hTERT; hTRT; PFBMFT1; RGD:70494}; TCS1; Telomerase catalytic subunit; telomerase reverse transcriptase; telomerase reverse transcriptase beta; telomerase-associated protein 2; TERT; tert {ECO:0000312; TP2; TR; TRT
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 7015
• Content And Storage: -20°C
• Form: Liquid

• Applications: Peptide ELISA, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: Dulbecco's PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: O14746
• Gene Symbols: TERT
• Immunogen: A synthetic phosphopeptide derived from human Telomerase around the phosphorylation site of Ser227 (G-G-SP-A-S).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG