Invitrogen™ Phospho-TERT (Tyr707) Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA513048

Catalog No. PIPA513048

Description

Phospho-TERT (Tyr707) Polyclonal Antibody for ICC/IF, DB

Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase (TERT) have been identified; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity.

Specifications

• Antigen: Phospho-TERT (Tyr707)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TERT
• Gene Alias: CMM9; DKCA2; DKCB4; EST2; HEST2; hTERT; hTRT; PFBMFT1; RGD:70494}; TCS1; Telomerase catalytic subunit; telomerase reverse transcriptase; telomerase reverse transcriptase beta; telomerase-associated protein 2; TERT; tert {ECO:0000312; TP2; TR; TRT
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography, Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 7015
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Dot Blot, Immunocytochemistry
• Concentration: 0.47 mg/mL
• Formulation: PBS with 0.09% sodium azide; pH 7.4
• Gene Accession No.: O14746
• Gene Symbols: TERT
• Immunogen: KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y707 of human TERT.
• Quantity: 400 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov