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Invitrogen™ Phospho-Thioredoxin 1 (Thr100) Polyclonal Antibody
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Catalog No. PIPA5105352
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Quantity:
100 μL
Catalog No. Quantity
PIPA5105352 100 μL
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Catalog No. PIPA5105352

Supplier: Invitrogen™ PA5105352

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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of TXN only when phosphorylated at Thr100.

Thioredoxins (Trx) are small, multi-functional proteins with oxidoreductase activity and are ubiquitous in essentially all living cells. Trx contains a redox-active disulfide/dithiol group within the conserved Cys-Gly-Pro-Cys active site. The two cysteine residues in the conserved active centers can be oxidized to form intramolecular disulfide bonds. Reduction of the active site disulfide in oxidized Trx is catalyzed by Trx reductase with NADPH as the electron donor. The reduced Trx is a hydrogen donor for ribonucleotide reductase, the essential enzyme for DNA synthesis, and a potent general protein disulfide reductase with numerous functions in growth and redox regulations. Specific protein disulfide targets for reduction by Trx include protein disulfide-isomerase (PDI) and a number of transcription factors such as p53, NF-kB and AP-1 (T1-151). Trx is also capable of removing H2O2, particularly when it is coupled with either methionine sulfoxide reductase or several isoforms of peroxiredoxins.
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Specifications

Antigen Phospho-Thioredoxin 1 (Thr100)
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene TXN
Gene Accession No. P10599, P10639, P11232
Gene Alias ADF; ATL-derived factor; AW550880; DKFZp686B1993; MGC61975; RP11-427L11.1; SASP; surface-associated sulphydryl protein; testicular tissue protein Li 199; thioredoxin; thioredoxin 1; thioredoxin delta 3; TRDX; TRX; TRX1; Txn; TXN delta 3; Txn1
Gene Symbols TXN, Txn1
Host Species Rabbit
Immunogen A synthesized peptide derived from human TXN(Accession P10599), corresponding to amino acid residues around phosphorylated Thr100.
Purification Method Sequential Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 116484, 22166, 7295
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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