Invitrogen™ Phospho-TLK1 (Ser741) Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5105771

Catalog No. PIPA5105771

Description

Antibody detects endogenous levels of TLK1 only when phosphorylated at Ser741.

TLK1 or tousled-like kinase 1 is a nuclear serine/threonine kinase that is potentially involved in the regulation of chromatin assembly. TLK1 is first described in Arabidopsis. TLK1 is a novel target of the DNA damage checkpoint that is rapidly inactivated upon exposure to ionizing radiation (IR) and the inactivation is directly mediated by the S-phase DNA damage checkpoint. The suppression of TLK1 activity after double-strand breaks in the DNA, replication blockade, or low doses of ultraviolet irradiation requires ATM, NBS and CHK1. The Tousled-like kinases, first described in Arabadopsis, are nuclear serine/threonine kinases that are potentially involved in the regulation of chromatin assembly.

Specifications

• Antigen: Phospho-TLK1 (Ser741)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TLK1
• Gene Alias: 4930545J15Rik; E(Sp1) homolog; Enhancer of split groucho-like protein 1; ESG; ESG1; GRG1; KIAA0137; PKU beta; PKU-beta; serine threonine protein kinase; serine/threonine-protein kinase tousled-like 1; SNAK; SNARE protein kinase SNAK; TLE1; TLK1; TLK-1; TLK1B; tousled like kinase 1; tousled-like kinase 1; transducin like enhancer of split 1; transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila); transducin-like enhancer protein 1
• Host Species: Rabbit
• Purification Method: sequential chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 228012, 311118, 9874
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: Q8C0V0, Q9UKI8
• Gene Symbols: TLK1
• Immunogen: A synthesized peptide derived from human TLK1(Accession Q9UKI8), corresponding to amino acid residues around phosphorylated Ser741.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov