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Invitrogen™ Phospho-TLR5 (Tyr798) Polyclonal Antibody
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Catalog No. PIPA5106049
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PIPA5106049 100 μL
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Catalog No. PIPA5106049 Supplier Invitrogen™ Supplier No. PA5106049
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of TLR5 only when phosphorylated at Tyr798.

TLR5 is a Type I membrane protein belonging to the Toll-like receptor family, participates in the innate immune response to microbial agents. TLR5 also plays a role in mediating detection of bacterial flagellins. TLR5 acts via MyD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. TLR5 protein binds to TIRAP and MyD88 via their respective TIR domains TLR5 is highly expressed in liver, and is detected in lung and at very low levels in most other tissues. The TLR5 gene lies in a locus that is associated with susceptibility to Salmonella. Inbred strains of mice can be classified into 3 categories according to their resistance to infection with S.typhimurium: susceptible (BALB/c, C57BL/6, C3H/He), intermediate (DBA/2, C75L) and resistant (A, CBA). The strain MOLF/Ei is highly susceptible to the infection, has a unique TLR5 haplotype and a lower expression of TRL5. A common TLR5 stop codon polymorphism that disrupts TLR5 signaling is associated with susceptibility to Legionnaires' disease and demonstrates the importance of TLR5 in the innate immune response.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-TLR5 (Tyr798)
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene TLR5
Gene Accession No. O60602, Q9JLF7
Gene Alias FLJ10052; MELIOS; MGC126430; MGC126431; RP11-239E10.1; SLE1; SLEB1; systemic lupus erythematosus susceptibility 1; TIL3; Tlr5; toll like receptor 5; Toll/interleukin-1 receptor-like protein 3; toll-like receptor 5
Gene Symbols TLR5
Host Species Rabbit
Immunogen A synthesized peptide derived from human TLR5(Accession O60602), corresponding to amino acid residues around phosphorylated Tyr798.
Purification Method Sequential chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 53791, 7100
Target Species Human, Mouse
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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