Invitrogen™ Phospho-TOP2A (Ser1469) Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5104672

Catalog No. PIPA5104672

Description

Antibody detects endogenous levels of TOP2A only when phosphorylated at Ser1469.

Topo II alpha plays important roles in synthesis and transcription of DNA as well as chromosomal segregation during mitosis. It is reported to be a sensitive and specific marker of late S-, G2 and M-phases in transformed and developmentally regulated normal cellsTopo II alpha is also implicated in drug resistance of tumor cells.

Specifications

• Antigen: Phospho-TOP2A (Ser1469)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TOP2A
• Gene Alias: DNA gyrase; DNA topoisomerase (ATP-hydrolyzing); DNA topoisomerase 2-alpha; DNA topoisomerase 2-alpha-like protein; DNA Topoisomerase II alpha; DNA topoisomerase II, 170 kD; DNA topoisomerase II, alpha isozyme; EC 5.99.1.3; OTTHUMP00000207108; P11388-1; TOP2; Top-2; Top2a; TOPOII; topoisomerase (DNA) 2 alpha; topoisomerase (DNA) II alpha; topoisomerase (DNA) II alpha 170kDa; topoisomerase ii alpha; topoisomersae II; TP2A
• Host Species: Rabbit
• Purification Method: sequential chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 21973, 7153
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: P11388, Q01320
• Gene Symbols: TOP2A
• Immunogen: A synthesized peptide derived from human TOP2A(Accession P11388), corresponding to amino acid residues around phosphorylated Ser1469.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov