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Invitrogen™ Phospho-TPPP (Ser18) Polyclonal Antibody
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Catalog No. PIPA5106051
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PIPA5106051 100 μL
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Catalog No. PIPA5106051 Supplier Invitrogen™ Supplier No. PA5106051
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of TPPP only when phosphorylated at Ser18.

Tubulin family members are globular proteins important in the assembly of microtubules. Microtubules are structural components that play important roles in mitosis, cytokinesis and vesicle transport. TPPP (Tubulin polymerization-promoting protein), also known as p24 and p25, is a widely expressed 219 amino acid protein found in the perinuclear region of the cytoplasm. TPPP may form dimers and functions in polymerizing tubulin into double-walled tubules, polymorphic aggregates, or stabilized blocks. TPPP overexpression prevents formation of the mitotic spindle assembly and breakdown of the nuclear envelope. TPPP is phosphorylated by TPK II and is encoded by a gene that maps to human chromosome 5, which contains 181 million base pairs and comprises nearly 6% of the human genome. May play a role in the polymerization of tubulin into microtubules, microtubule bundling and the stabilization of existing microtubules, thus maintaining the integrity of the microtubule network. May play a role in mitotic spindle assembly and nuclear envelope breakdown.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-TPPP (Ser18)
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene TPPP
Gene Accession No. O94811, Q7TQD2
Gene Alias 25 kDa brain-specific protein; 2900041A09Rik; AI849835; brain specific protein p25 alpha; brain-specific protein p25 alpha; glycogen synthase kinase 3 (GSK3) inhibitor p24; p24; p25; p25alpha; p25-alpha; RGD1310121; Tppp; TPPP/p25; TPPP1; tubulin polymerization promoting protein; tubulin polymerization-promoting protein
Gene Symbols TPPP
Host Species Rabbit
Immunogen A synthesized peptide derived from human TPPP(Accession O94811), corresponding to amino acid residues around phosphorylated Ser18.
Purification Method Sequential Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 11076, 361466, 72948
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

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