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Invitrogen™ Phospho-TPT1 (Ser53) Polyclonal Antibody
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Catalog No. PIPA5105492
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100 μL
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PIPA5105492 100 μL
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Catalog No. PIPA5105492 Supplier Invitrogen™ Supplier No. PA5105492
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of TCTP only when phosphorylated at Ser53.

TPT1 (translationally controlled tumor protein 1) is a 23 kDa member of the TCTP family of calcium binding proteins. TPT1 is localized in the cytoplasm and widely expressed and serves as a transcriptional activator, calcium transporter, histamine inducer and antiapoptotic caspase 3 inhibitor. TPT1 is a cytokine-like molecule that causes the release of histamine, IL-4 and IL-13 from basophils as well as the secretion of IL-8 and a calcium response in eosinophils. TPT1 plays a pivotal role in allergic diseases and due to its wide distribution in brain, is thought to be involved in neurodegenerative disorders, such as Alzheimer's disease and Down syndrome.
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Specifications

Antigen Phospho-TPT1 (Ser53)
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene TPT1
Gene Accession No. P13693, P63028, P63029
Gene Alias 21 kDa polypeptide; 21 kDa polypeptide under translational control; fortilin; Histamine-releasing factor; HRF; Lens epithelial protein; p02; p21; p23; TCTP; Tpt1; translationally regulated transcript (21 kDa); translationally-controlled tumor protein; Trt; tumor protein, translationally-controlled 1
Gene Symbols TPT1
Host Species Rabbit
Immunogen A synthesized peptide derived from human TPT1(Accession P13693), corresponding to amino acid residues around phosphorylated Ser53.
Purification Method Sequential chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 116646, 22070, 7178
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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