Invitrogen™ Phospho-Trf2 (Ser365) Polyclonal Antibody

Catalog No.	Quantity
PIPA5106214	100 μL

Catalog No. PIPA5106214 Supplier Invitrogen™ Supplier No. PA5106214

Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of TRF2 only when phosphorylated at Ser365, which site historically referenced as Ser323.

TRF2 is a ubiquitously expressed protein that is implicated in the control of telomere length. TRF2, like TRF1 contains a Myb-related DNA binding motif. It binds to duplex TTAGGG repeats and is localized to all human telomeres in metaphase chromosomes. TRF2 is thought to protect chromosome ends by maintaining the correct structure at telomere termini. The use of mutant forms of TRF2 has implicated a role for TRF2 in the prevention of senescence in primary human cells. Recently, it has been shown that inhibition of TRF2 resulted in apoptosis in a subset of mammalian cell types.

Specifications

• Antigen: Phospho-Trf2 (Ser365)
• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Classification: Polyclonal
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene: TERF2
• Gene Accession No.: O35144, Q15554
• Gene Alias: Telomeric DNA-binding protein; telomeric repeat binding factor 2; telomeric repeat binding protein 2; telomeric repeat-binding factor 2; TERF2; TRBF2; TRF2; TTAGGG repeat-binding factor 2
• Gene Symbols: TERF2
• Host Species: Rabbit
• Immunogen: A synthesized peptide derived from human TERF2(Accession Q15554), corresponding to amino acid residues around phosphorylated Ser365.
• Purification Method: Sequential Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 21750, 7014
• Target Species: Human, Mouse
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG