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Invitrogen™ H3K9me3S10ph Recombinant Rabbit Monoclonal Antibody (RM162)
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Catalog No. PIMA533083
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100 μg
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PIMA533083 100 μg
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Catalog No. PIMA533083 Supplier Invitrogen™ Supplier No. MA533083
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Description

Rabbit Recombinant Monoclonal Antibody

Specificity: reacts to Histone H3 only when modified AT both trimethyl lysine 9 and phospho serine 10 (K9me3/S10p). Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

Histone H3 is one of the DNA-binding proteins found in the chromatin of all eukaryotic cells. H3 along with four core histone proteins binds to DNA forming the structure of the nucleosome. Histones play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. Post translationally, histones are modified in a variety of ways to either directly change the chromatin structure or allow for the binding of specific transcription factors. The N-terminal tail of histone H3 protrudes from the globular nucleosome core and can undergo several different types of post-translational modification that influence cellular processes. These modifications include the covalent attachment of methyl or acetyl groups to lysine and arginine amino acids and the phosphorylation of serine or threonine.
TRUSTED_SUSTAINABILITY

Specifications

Antigen H3K9me3S10ph
Applications ELISA, Western Blot, Luminex
Classification Recombinant Monoclonal
Clone RM162
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.09% sodium azide
Gene H3C15
Gene Accession No. P68431, P68433, P84228, Q71DI3
Gene Alias H3; H3 histone; H3 histone family, member A; H3 histone family, member I; H3 histone family, member K; H3 histone family, member L; H3 histone family, member M; H3 histone, family 2; H3 histone, family 3A; H3 histone, family 3B; H3 histone, family 3B (H3.3B); H3 histone, family 3C; H3 K9; H3 K9me3; H3 S10; H3 S10ph; H3.1-221; H3.1-291; H3.1-I; H3.2; H3.2-221; H3.2-614; H3.2-615; H3.2-616; H3.3A; H3.3b; H3.5; H3/A; H3/b; H3/d; H3/f; H3/i; H3/j; H3/k; H3/l; H3/M; H3/n; H3/o; H3-143; H3-291; H3-3A; H3-3B; H3-53; H3-614; H3a; H3b; H3-B; H3c1; H3c10; H3c11; H3C12; H3C2; H3C3; H3C4; H3C6; H3C7; H3c8; H3f; H3-F; H3F1K; H3F2; H3F3; H3F3A; H3F3B; H3F3C; H3FA; H3FB; H3FC HIST1H3C; H3FD; H3FF; H3FH; H3FI; H3FJ; H3FK; H3FL; H3FM; H3FN; H3g; H3h; H3i; H3K9; H3K9me3; H3K9me3S10p; H3K9trS28p; H3K9trS28ph; H3Lys9me3Ser10p; H3Lys9me3Ser10ph; H3Lys9trSer28p; H3Lys9trSer28ph; H3s10; H3S10ph; Hist1; Hist1h2ai; Hist1h2ail; Hist1h2ail1; Hist1h3a; HIST1H3B; Hist1h3c; HIST1H3D; HIST1H3E; HIST1H3F; Hist1h3g; HIST1H3H; Hist1h3i; HIST1H3J; HIST2H3A; Hist2h3b; HIST2H3C; Hist2h3c1; Hist2h3c2; Hist2h3c2-ps; Hist2h3ca1; Hist2h3ca2; HIST2H3D; histone 1, H2ai; histone 1, H3a; histone 1, H3b; histone 1, H3f; histone 1, H3h; histone 2, H3a; histone 2, H3c; histone 2, H3c2; histone 2, H3ca2; Histone 3; histone cluster 1, H2ai; histone cluster 1, H2ai-like; histone cluster 1, H2ai-like1; histone cluster 1, H3a; histone cluster 1, H3b; histone cluster 1, H3f; histone cluster 1, H3h; histone cluster 2, H3a; histone cluster 2, H3c; histone cluster 2, H3c2; histone cluster 2, H3c2, pseudogene; histone gene complex 1; histone H3; Histone H3 K9; Histone H3 K9me3; Histone H3 S10; Histone H3 S10ph; histone H3.1; Histone H3.2; histone H3.3; Histone H3.3C; histone H3.5; Histone H3/a; Histone H3/b; Histone H3/c; Histone H3/d; Histone H3/f; Histone H3/h; Histone H3/i; Histone H3/j; Histone H3/k; histone H3/l; Histone H3/m; histone H3/o; Histone H3K9; Histone H3K9me3; Histone H3K9me3S10ph; Histone H3S10; Histone H3S10ph; histone variant H3.5; M32461; methyl Histone 3; methyl Histone H3; phospho Histone 3; phospho Histone H3; Phospho-Tri-Methyl-H3 K9 S10; Phospho-Tri-Methyl-H3 Lys9 Ser10; Phospho-Tri-Methyl-Histone H3 K9 S10; Phospho-Tri-Methyl-Histone H3 Lys9 Ser10; Phospho-Tri-Methyl-Histone H3 S10 K9; Phospho-Tri-Methyl-Histone H3 S28 K27; Phospho-Tri-Methyl-Histone H3 Ser10 Lys9; Phospho-Tri-Methyl-Histone H3 Ser28 Lys27; PP781; Trimethyl H3; Tri-methyl H3; Trimethyl Histone H3; Tri-methyl Histone H3
Gene Symbols H3C1, H3C10, H3C12, H3C14, H3C15, H3C2, H3C7, Hist1h2ail1
Host Species Rabbit
Immunogen A trimethyl-phospho-peptide corresponding to Trimethyl- Phospho-Histone H3 (Lys9/Ser10).
Purification Method Protein A
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 126961, 260423, 291159, 310678, 319150, 319152, 333932, 360198, 679994, 8350, 8356, 8357, 8358, 8968, 97114
Target Species Human, Mouse, Rat, All species
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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