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Invitrogen™ Phospho-TRIM28 (Ser824) Recombinant Rabbit Monoclonal Antibody (JE50-99)
Rabbit Recombinant Monoclonal Antibody
Supplier: Invitrogen™ MA541173
Description
This product is predicted to work in Immunoprecipitation at a dilution of 1:10-1:50.
The KRAB (Kruppel-associated box) domain is about 45 amino acids in length and is a transcriptional repression domain found in numerous transcription factors. There have been identified over 220 KRAB-zinc finger protein (KRAB-ZFP) genes in the human genome. These proteins functionally repress transcription via specific interactions with KAP-1 (KRAB-associated protein 1). KAP-1 is an 835 amino acid polypeptide that contains a RING finger, B boxes, and a PHD finger. KAP-1 has been shown to form complexes with KRAB-domain transcription factors and increase the efficiency with which they mediate repression. KAP-1 has also been shown to directly interact with HP1 (heterochromatin protein 1) and KRAZ1 (Kruppel-associated box-containing zinc finger protein 1). KAP-1 directly targets KRAZ1 to the foci of centromeric heterochromatin containing HP1alpha, thus helping to regulate transcriptional repression. Studies have shown that KAP-1 mutants with the ability to bind KRAB but unable to bind HP1 leads to random distribution of KRAZ1 and strong transcriptional activation.
Specifications
Phospho-TRIM28 (Ser824) | |
Recombinant Monoclonal | |
1 mg/mL | |
TBS with 0.05% BSA, 40% glycerol and 0.05% sodium azide; pH 7.4 | |
Q13263 | |
TRIM28 | |
Synthetic phospho-peptide corresponding to residues surrounding Ser824 of human KAP1. | |
100 μL | |
Primary | |
Human | |
Antibody | |
IgG |
Dot Blot, Immunohistochemistry (Paraffin), Western Blot | |
JE50-99 | |
Unconjugated | |
TRIM28 | |
AA408787; E3 SUMO-protein ligase TRIM28; KAP1; KAP-1; KRAB [Kruppel-associated box domain]-associated protein 1; KRAB-A-interacting protein; KRAB-associated protein 1; KRAB-interacting p; KRAB-interacting protein 1; Krip1; KRIP-1; MommeD9; Nuclear corepressor KAP-1; PPP1R157; protein phosphatase 1, regulatory subunit 157; RING finger protein 96; RING-type E3 ubiquitin transferase TIF1-beta; RNF96; TF1B; tif1 beta; Tif1b; Tif1beta; TIF1-beta; Transcription intermediary factor 1-beta; transcriptional intermediary factor 1, beta; transcriptional intermediary factor 1-beta; Trim28; tripartite motif; tripartite motif containing 28; tripartite motif protein 28; tripartite motif-containing 28; tripartite motif-containing protein 28 | |
Rabbit | |
Protein A | |
RUO | |
10155 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |
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