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Invitrogen™ Phospho-TrkA/TrkB (Tyr674, Tyr675, Tyr706, Tyr707) Monoclonal Antibody (C.795.3)
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Catalog No. PIMA514927
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100 μL
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PIMA514927 100 μL
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Catalog No. PIMA514927 Supplier Invitrogen™ Supplier No. MA514927
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Description

Rabbit Monoclonal Antibody

It is not recommended to aliquot this antibody.

This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date.
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Specifications

Antigen Phospho-TrkA/TrkB (Tyr674, Tyr675, Tyr706, Tyr707)
Applications Immunoprecipitation, Western Blot
Classification Monoclonal
Clone C.795.3
Concentration 36 μg/mL
Conjugate Unconjugated
Formulation 0.01M HEPES with 100μg/mL BSA, 50% glycerol, 0.15M NaCl and <0.02% sodium azide; pH 7.5
Gene NTRK1
Gene Accession No. P04629, P35739, Q16620, Q63604
Gene Alias BDNF/NT-3 growth factors receptor; BDNF-tropomyosine receptor kinase B; C80751; gp140trk; GP145-TrkB; GP145-TrkB/GP95-TrkB; high affinity nerve growth factor receptor; MTC; neural receptor protein-tyrosine kinase (trkB); neurotrophic receptor tyrosine kinase 1; neurotrophic receptor tyrosine kinase 2; Neurotrophic tyrosine kinase receptor type 1; Neurotrophic tyrosine kinase receptor type 2; neurotrophic tyrosine kinase, receptor, type 1; neurotrophic tyrosine kinase, receptor, type 2; neurotrophic tyrosine receptor kinase type 2; NTRK1; NTRK2; Oncogene TRK; p140-TrkA; RATTRKB1; Slow nerve growth factor receptor; Tkr; Tkrb; trk; TRK1; TRK1-transforming tyrosine kinase protein; Trka; trk-A; TrkA neurotrophin receptor; trkA proto-oncogene receptor; TRKB; Trk-B; TrkB tyrosine kinase; TRKB1; Tropomyosin-related kinase A; tropomyosin-related kinase B; Tyrosine kinase receptor; Tyrosine kinase receptor A; tyrosine kinase receptor B
Gene Symbols NTRK1, Ntrk2
Host Species Rabbit
Immunogen Synthetic phosphopeptide corresponding to residues surrounding pTyr674/675 of human TrkA.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 25054, 4914, 4915, 59109
Target Species Human, Rat, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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