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Invitrogen™ Phospho-TrkA/TrkB (Tyr785, Tyr816) Polyclonal Antibody
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Catalog No. PIPA5105133
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PIPA5105133 100 μL
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Catalog No. PIPA5105133 Supplier Invitrogen™ Supplier No. PA5105133
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of TrkA /TrkB only when phosphorylated at Tyr785.

This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date.
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Specifications

Antigen Phospho-TrkA/TrkB (Tyr785, Tyr816)
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene NTRK1
Gene Accession No. P04629, P15209, P35739, Q16620, Q3UFB7, Q63604
Gene Alias BDNF/NT-3 growth factors receptor; BDNF-tropomyosine receptor kinase B; C80751; gp140trk; GP145-TrkB; GP145-TrkB/GP95-TrkB; high affinity nerve growth factor receptor; MTC; neural receptor protein-tyrosine kinase (trkB); neurotrophic receptor tyrosine kinase 1; neurotrophic receptor tyrosine kinase 2; Neurotrophic tyrosine kinase receptor type 1; Neurotrophic tyrosine kinase receptor type 2; neurotrophic tyrosine kinase, receptor, type 1; neurotrophic tyrosine kinase, receptor, type 2; neurotrophic tyrosine receptor kinase type 2; NTRK1; NTRK2; Oncogene TRK; p140-TrkA; RATTRKB1; Slow nerve growth factor receptor; Tkr; Tkrb; trk; TRK1; TRK1-transforming tyrosine kinase protein; Trka; trk-A; TrkA neurotrophin receptor; trkA proto-oncogene receptor; TRKB; Trk-B; TrkB tyrosine kinase; TRKB1; Tropomyosin-related kinase A; tropomyosin-related kinase B; Tyrosine kinase receptor; Tyrosine kinase receptor A; tyrosine kinase receptor B
Gene Symbols NTRK1, Ntrk2
Host Species Rabbit
Immunogen A synthesized peptide derived from human NTRK1(Accession P04629), corresponding to amino acid residues around phosphorylated Tyr785.
Purification Method Sequential chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 18211, 18212, 25054, 4914, 4915, 59109
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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