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Invitrogen™ Phospho-TrkA (Tyr496) Polyclonal Antibody
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Catalog No. PIPA5105132
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PIPA5105132 100 μL
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Catalog No. PIPA5105132 Supplier Invitrogen™ Supplier No. PA5105132
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of TrkA only when phosphorylated at Tyr496.

NTRK1 (TRKA) belongs to the neurotrophic factor family of related polypeptides central to the development and maintenance of the mammalian nervous system. TrkA is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of TrkA leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in TrkA have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer.
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Specifications

Antigen Phospho-TrkA (Tyr496)
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Ntrk1
Gene Accession No. P04629, P35739, Q3UFB7
Gene Alias C80751; DKFZp781I14186; EC 2.7.10.1; gp140trk; high affinity nerve growth factor receptor; kinase TrkA; MTC; neurotrophic receptor tyrosine kinase 1; Neurotrophic tyrosine kinase receptor type 1; neurotrophic tyrosine kinase, receptor, type 1; Ntrk1; Oncogene TRK; p140-TrkA; Slow nerve growth factor receptor; Tkr; TRK; TRK1; TRK1-transforming tyrosine kinase protein; Trka; Trk-A; TrkA neurotrophin receptor; trkA proto-oncogene receptor; tropomyosin-related kinase A; Tyrosine kinase receptor; Tyrosine kinase receptor A
Gene Symbols Ntrk1
Host Species Rabbit
Immunogen A synthesized peptide derived from human NTRK1(Accession P04629), corresponding to amino acid residues around phosphorylated Tyr496.
Purification Method Sequential chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 18211, 4914, 59109
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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