Phospho-Troponin I (Ser23, Ser24) Rabbit anti-Human, Polyclonal, Bioss

Rabbit Polyclonal Antibody

Supplier:  Bioss BS3458R

Catalog No. 50-198-5420

Description

Troponin proteins associate with tropomyosin and regulate the calcium sensitivity of the myofibril contractile apparatus of striated muscles. Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. The TnI-fast and TnI-slow genes are expressed in fast-twitch and slow-twitch skeletal muscle fibers, respectively, while the TnI-cardiac gene is expressed exclusively in cardiac muscle tissue. This gene encodes the Troponin-I-skeletal-slow-twitch protein. This gene is expressed in cardiac and skeletal muscle during early development but is restricted to slow-twitch skeletal muscle fibers in adults. The encoded protein prevents muscle contraction by inhibiting calcium-mediated conformational changes in actin-myosin complexes.

Specifications

• Antigen: Phospho-Troponin I (Ser23, Ser24)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TNNI3
• Gene Alias: 2700018B22Rik; AI747285; BOS_15991; BOS_18114; Cardiac troponin I; cardiac troponin I isoform; cardiomyopathy, dilated 2A (autosomal recessive); CMD1FF; CMD2A; CMH7; Ctni; DKFZp451O223; LOC511094; RCM1; slow skeletal troponin I isoform; SSTNI; Tn1; Tni; TNN1; TNNC1; Tnni1; TNNI3; Tpn1; troponin 1, type 3; troponin I type 1 (skeletal, slow); troponin I type 3 (cardiac); troponin I, cardiac 3; Troponin I, cardiac muscle; troponin I, cardiac muscle-like; troponin I, skeletal, slow 1; Troponin I, slow isoform; troponin I, slow skeletal; Troponin I, slow skeletal muscle; Troponin I, slow-twitch isoform; troponin I1, slow skeletal type; troponin I3, cardiac type
• Host Species: Rabbit
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 7135, 7137
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 μg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
• Gene Accession No.: P19237, P19429
• Gene Symbols: TNNI1, TNNI3
• Immunogen: KLH conjugated synthetic phosphopeptide derived from human Troponin I around the phosphorylation site of Ser23/24.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG