Invitrogen™ Phospho-TYK2 (Tyr433) Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5105556

Catalog No. PIPA5105556

Description

Antibody detects endogenous levels of TYK2 only when phosphorylated at Tyr433.

Tyrosine Kinase 2 (TYK2) a member of the JAK kinase family, plays both structural and catalytic roles in type I interferon (IFN) signaling. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E.

Specifications

• Antigen: Phospho-TYK2 (Tyr433)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TYK2
• Gene Alias: 4833430L21Rik; AW540162; BRE1; BRE1A; C79397; hBRE1; IMD35; JTK1; mKIAA4116; Non-receptor tyrosine-protein kinase TYK2; Tyk2; tyrosine kinase 2; tyrosine kinase TYK2
• Host Species: Rabbit
• Purification Method: Sequential Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 54721, 7297
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: P29597, Q9R117
• Gene Symbols: TYK2
• Immunogen: A synthesized peptide derived from human TYK2(Accession P29597), corresponding to amino acid residues around phosphorylated Tyr433.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG