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Invitrogen™ Phospho-Tyrosine Hydroxylase (Ser40) Polyclonal Antibody
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Catalog No. 368600
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36-860-0 100 μL
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Catalog No. 36-860-0 Supplier Invitrogen™ Supplier No. 368600
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Description

Rabbit Polyclonal Antibody

Phospho-Tyrosine Hydroxylase (Ser40) Polyclonal Antibody for ELISA, ICC/IF, IHC, Western Blot

Tyrosine hydroxylase (TH) is an enzyme involved in the synthesis of catecholamine neurotransmitters dopamine, epinephrine, and norepinephrine. In all species, catecholamine synthesis is regulated by the interaction of TH with a cofactor, tetrahydrobiopterin (BH4). BH4 binds to the TH catalytic domain, resulting in enzymatic activity. Unlike TH in non-primate species, four human TH mRNA splice variants (hTH1-hTH4) have been isolated. These variants are identical in their catalytic domain, but differ in their N-terminal, regulatory domains. TH is also responsible for the conversion of L-tyrosine to L-dopa. TH plays a key role in the physiology of adrenergic neurons. The role of TH in the synthesis of catecholamine neurotransmitters suggests a correlation between the enzyme and a number of neuropathogenic diseases including: Parkinson's disease, schizophrenia, Segawa syndrome, and dystonia, as well as a variety of cardiovascular diseases.
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Specifications

Antigen Phospho-Tyrosine Hydroxylase (Ser40)
Applications ELISA, Immunohistochemistry, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.3 mg/mL
Conjugate Unconjugated
Formulation 0.01M HEPES with 0.15M NaCl, 100 μg/mL BSA, 50% glycerol and no preservative, pH 7.5
Gene TH
Gene Accession No. P04177
Gene Alias dystonia 14; DYT14; DYT5b; EC 1.14.16.2; HGNC:11782; Th; TH isoform 3; TH isoform a; th1; TH-4; The; TY3H; TYH; TYH antibody; Tyrosine 3-hydroxylase; tyrosine 3-monooxygenase; tyrosine hydroxylase
Gene Symbols TH
Host Species Rabbit
Immunogen Synthetic phospho-peptide derived from the rat tyrosine hydroxylase (TH) protein (aa 40).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 25085
Target Species Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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