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Invitrogen™ Phospho-VAMP4 (Ser88) Polyclonal Antibody
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Catalog No. PIPA5105419
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100 μL
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PIPA5105419 100 μL
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Catalog No. PIPA5105419 Supplier Invitrogen™ Supplier No. PA5105419
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of VAMP4 only when phosphorylated at Ser88.

The vesicle associated membrane proteins (VAMP) or synaptobrevins are calcium binding proteins specific to eukaryotes. VAMPs, along with synaptosomal associated protein of 25 kDa (SNAP-25) and syntaxin, form the core complex of soluble NSF attachment protein receptor (SNARE) proteins that interact with the soluble proteins N-ethylmaleimide-sensitive factor (NSF) and alpha-SNAP. These membrane associated proteins play a key role in the regulation of vesicle membrane fusion with the plasma membrane. The Clostridium tetani neurotoxin is a metalloprotease with specificity for VAMP. In Alzheimer's disease, VAMP levels of all isoforms appear to be significantly lowered.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-VAMP4 (Ser88)
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene VAMP4
Gene Accession No. O70480, O75379
Gene Alias D1Ertd147e; vamp; VAMP24; VAMP4; VAMP-4; vesicle associated membrane protein 4; vesicle-associated membrane protein 4
Gene Symbols VAMP4
Host Species Rabbit
Immunogen A synthesized peptide derived from human VAMP4(Accession O75379), corresponding to amino acid residues around phosphorylated Ser88.
Purification Method Sequential Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 364033, 53330, 8674
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

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