Invitrogen™ Phospho-VANGL2 (Ser14, Ser17) Recombinant Rabbit Monoclonal Antibody (4C7Y1)

Catalog No.	Quantity
PIMA542957	100 μL

Catalog No. PIMA542957

Supplier: Invitrogen™ MA542957

Description

Rabbit Recombinant Monoclonal Antibody

Positive test controls include: HeLa. The target is usually found in the following locations: Cell membrane, Multi-pass membrane protein.

Van Gogh is an alternate name for the Drosophila strabismus protein. Van Gogh like-2 (VANGL2) is a 521 amino acidprotein in vertebrates similar to strabismus 1 of Drosophila and a component of the frizzled-disheveled tissue polarity pathway. It interacts through it's C-terminal region with the N-terminal half of DVL1, DVL2 and DVL3 and is a potent tumor suppressor. It ispredominantly involved in the control of early morphogenesis and patterning of both axial midline structures and the development of neural plate. It plays a crucial role in the regulation of planar cell polarity, particularly in the orientation of stereociliary bundles in the cochlea. VANGL2 is required for polarization and movement of myocardializing cells and seems to act via RHOA signaling to regulate this process. It is expressed in a wide range of tissues.

Specifications

• Antigen: Phospho-VANGL2 (Ser14, Ser17)
• Applications: ELISA, Western Blot
• Classification: Recombinant Monoclonal
• Clone: 4C7Y1
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 0.05% BSA, 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene: Vangl2
• Gene Accession No.: Q9ULK5
• Gene Alias: C530001F03Rik; KIAA1215; loop tail associated protein; loop-tail; Loop-tail protein 1; loop-tail protein 1 homolog; Loop-tail-associated protein; Lp; LPP1; Ltap; MGC119403; MGC119404; RGD:1309442}; ska>m17Jus>; ska17; STB1; stbm; STBM1; strabismus; Strabismus 1; van Gogh-like protein 2; vang; vang (van gogh)-like 2; Vang1l2; VANGL planar cell polarity protein 2; Vangl2; vangl2 {ECO:0000312; vang-like 2 (van gogh, Drosophila); vang-like protein 2
• Gene Symbols: Vangl2
• Host Species: Rabbit
• Immunogen: A phospho specific peptide corresponding to residues surrounding S14/S17 of human VANGL2.
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 57216
• Target Species: Human
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG