Invitrogen™ Phospho-VASP (Thr278) Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA564771

Catalog No. PIPA564771

Description

Phospho-VASP (Thr278) Polyclonal Antibody detects endogenous levels of VASP only when phosphorylated at Thr278.

Vasodilator-stimulated phosphoprotein (VASP) is a member of the Ena-VASP protein family. Ena-VASP family members contain an EHV1 N-terminal domain that binds proteins containing E/DFPPPPXD/E motifs and targets Ena-VASP proteins to focal adhesions. In the mid-region of the protein, family members have a proline-rich domain that binds SH3 and WW domain-containing proteins. Their C-terminal EVH2 domain mediates tetramerization and binds both G and F actin. VASP is associated with filamentous actin formation and likely plays a widespread role in cell adhesion and motility. VASP may also be involved in the intracellular signaling pathways that regulate integrin-extracellular matrix interactions. VASP is regulated by the cyclic nucleotide-dependent kinases PKA and PKG.

Specifications

• Antigen: Phospho-VASP (Thr278)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: VASP
• Gene Alias: Enah/Vasp-like; I79_012660; Unknown (protein for MGC:127789); vasodilator stimulated phosphoprotein; vasodilator-stimulated phosphoprotein; vasodilator-stimulated phosphoprotein (VASP); VASP
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 22323, 361517, 7408
• Content And Storage: -20°C
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: P50552, P70460
• Gene Symbols: VASP
• Immunogen: A synthesized peptide derived from human VASP (Phospho-Thr278).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG