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Phospho-Vimentin (Ser56) Rabbit anti-Human, Polyclonal, Bioss
SDP

Catalog No. 501985430
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50-198-5430 100 μL
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Catalog No. 50-198-5430 Supplier Bioss Supplier No. BS3471R
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Rabbit Polyclonal Antibody

Vimentin is a developmentally regulated intermediate filament protein (IFP) found in cells of mesenchymal origin. It is believed to be involved with the intracellular transport of proteins between the nucleus and plasma membrane. Unlike other IFP proteins, vimentin is expressed, along with desmin, during the early stages of cellular development. During the development process, vimentin is exchanged for new, tissue-specific IFPs. Vimentin has been implicated to be involved in the rate of steroid synthesis via its role as a storage network for steroidogenic cholesterol containing lipid droplets. Vimentin phosphorylation by a protein kinase causes the breakdown of intermediate filaments and activation of an ATP and myosin light chain dependent contractile event. This results in cytoskeletal changes that facilitate the interaction of the lipid droplets within mitochondria, and subsequent transport of cholesterol to the organelles leading to an increase in steroid synthesis.

Specifications

Antigen Phospho-Vimentin (Ser56)
Applications Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 μg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene Vim
Gene Accession No. P08670
Gene Alias BOS_12844; cb28; CTRCT30; epididymis luminal protein 113; FLJ36605; HEL113; intermediate filament; RP11-124N14.1; Vim; VIME; Vimentin
Gene Symbols Vim
Host Species Rabbit
Immunogen KLH conjugated synthetic phosphopeptide derived from human Vimentin around the phosphorylation site of Ser56.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 7431
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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