Invitrogen™ Phospho-WASP (Tyr291) Polyclonal Antibody

Catalog No.	Quantity
PIPA5105572	100 μL

Catalog No. PIPA5105572 Supplier Invitrogen™ Supplier No. PA5105572

Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of WASP only when phosphorylated at Tyr291.

The Wiskott-Aldrich syndrome family of proteins share similar domain structure, and are involved in transduction of signals from receptors on the cell surface to the actin cytoskeleton. The presence of a number of different motifs suggests that they are regulated by a number of different stimuli, and interact with multiple proteins. Recent studies have demonstrated that these proteins, directly or indirectly, associate with the small GTPase, Cdc42, known to regulate formation of actin filaments, and the cytoskeletal organizing complex, Arp2/3. Wiskott-Aldrich syndrome is a rare, inherited, X-linked, recessive disease characterized by immune dysregulation and microthrombocytopenia, and is caused by mutations in the WAS gene. The WAS gene product is a cytoplasmic protein, expressed exclusively in hematopoietic cells, which show signalling and cytoskeletal abnormalities in WAS patients. A transcript variant arising as a result of alternative promoter usage, and containing a different 5' UTR sequence, has been described, however, its full-length nature is not known.

Specifications

• Antigen: Phospho-WASP (Tyr291)
• Applications: Immunohistochemistry (Paraffin), Western Blot
• Classification: Polyclonal
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene: Was
• Gene Accession No.: P42768, P70315
• Gene Alias: 2900021I12Rik; 3110031I02Rik; eczema-thrombocytopenia; IMD2; neural Wiskott-Aldrich syndrome protein; NWASP; N-WASP; SCNX; THC; THC1; thrombocytopenia 1 (X-linked); TRS4; U42471; Was; WASL; Wasp; WASPA; WASPB; Wiskott-Aldrich syndrome; Wiskott-Aldrich syndrome homolog; Wiskott-Aldrich syndrome homolog (human); Wiskott-Aldrich syndrome like; wiskott-Aldrich syndrome protein; Wiskott-Aldrich syndrome protein homolog; Wiskott-Aldrich syndrome-like; Wiskott-Aldrich syndrome-like (human)
• Gene Symbols: Was
• Host Species: Rabbit
• Immunogen: A synthesized peptide derived from human WAS(Accession P42768), corresponding to amino acid residues around phosphorylated Tyr291.
• Purification Method: sequential chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 22376, 317371, 7454
• Target Species: Human, Mouse, Rat
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov