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Invitrogen™ Phospho-WWC1 (Ser947) Polyclonal Antibody
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Catalog No. PIPA5105068
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100 μL
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PIPA5105068 100 μL
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Catalog No. PIPA5105068 Supplier Invitrogen™ Supplier No. PA5105068
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of KIBRA only when phosphorylated at Ser947.

WWC1 (Protein KIBRA) is a probable regulator of the Hippo/SWH signaling pathway. This pathway plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. WWC1, along with NF2, can synergistically induce the phosphorylation of LATS1 and LATS2. It acts as a transcriptional coactivator of ESR1 - which plays an essential role in DYNLL1-mediated ESR1 transactivation. WWC1 also functions as a regulatior of collagen-stimulated activation of the ERK/MAPK cascade.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-WWC1 (Ser947)
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene WWC1
Gene Accession No. Q5SXA9, Q8IX03
Gene Alias AA408228; AU017197; BC037006; FLJ10865; FLJ23369; HBeAg-binding protein 3; HBEBP3; HBEBP36; Kiaa0869; KIBRA; Kidney and brain protein; MEMRYQTL; mKIAA0869; PPP1R168; Protein KIBRA; protein phosphatase 1, regulatory subunit 168; protein WWC1; RGD1308329; WW and C2 domain containing 1; WW domain-containing protein 1; WW, C2 and coiled-coil domain containing 1; WWC1
Gene Symbols WWC1
Host Species Rabbit
Immunogen A synthesized peptide derived from human WWC1(Accession Q8IX03), corresponding to amino acid residues around phosphorylated Ser947.
Purification Method Sequential Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 211652, 23286, 303039
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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