Invitrogen™ Phospho-XRCC4 (Ser260) Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5118724

Catalog No. PIPA5118724

Description

Antibody detects endogenous levels of XRCC4 only when phosphorylated at Ser260.

The x-ray repair cross-complementing (XRCC) proteins are responsible for efficiently repairing and maintaining genetic stability following DNA base damage. These genes share sequence similarity with the yeast DNA repair protein Rad51. XRCC4 is an accessory factor of DNA ligase IV that preferentially binds DNA with nicks or broken ends. XRCC4 binds to DNA ligase IV and enhances its joining activity, and it is also involved in V(D)J recombination. Any defect in one of the known components of the DNA repair/V(D)J recombination machinery (Ku-70, Ku-80, DNA-PKCS, XRCC4 and DNA ligase IV) leads to abortion of the V(D)J rearrangement process and early block in both T and B cell maturation.

Specifications

• Antigen: Phospho-XRCC4 (Ser260)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: XRCC4
• Gene Alias: 2310057B22Rik; AW413319; AW545101; DNA repair protein XRCC4; SSMED; X-ray repair complementing defective repair in Chinese hamster cells 4; X-ray repair cross complementing 4; X-ray repair cross complementing protein 4; X-ray repair cross-complementing protein 4; XRCC4
• Host Species: Rabbit
• Purification Method: sequential chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 108138, 309995, 7518
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: Q13426, Q924T3
• Gene Symbols: XRCC4
• Immunogen: A synthesized peptide derived from human XRCC4(Accession Q13426), corresponding to amino acid residues around phosphorylated Ser260.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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