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Phospho-ZAP70 (Tyr493) Rabbit anti-Human, Polyclonal, Bioss
SDP

Catalog No. 501985436
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50-198-5436 100 μL
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Catalog No. 50-198-5436 Supplier Bioss Supplier No. BS3479R
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Description

Rabbit Polyclonal Antibody

ZAP70, a 70 kDa member of the Syk tyrosine kinase family, plays a central role in lymphocyte activation and development, and is implicated in several immune disorders. Upon T cell antigen receptor (TCR) engagement, ZAP70 is phosphorylated on tyrosines 292, 315 and 319 in the interdomain B, located between the SH2 and kinase domains. Phosphorylation of both tyrosines 315 (a Vav binding site) and 319 (a Lck binding site) enhances ZAP70 function in mediating lymphocyte signaling, while tyrosine 292 terminates the transient activation of ZAP70 and attentuates lymphocyte signaling.

Specifications

Antigen Phospho-ZAP70 (Tyr493)
Applications Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 μg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene ZAP70
Gene Accession No. P43403
Gene Alias 70 kDa zeta-associated protein; 70 kDa zeta-chain associated protein; ADMIO2; BOS_11303; EC 2.7.10.2; FLJ17670; FLJ17679; I79_004087; IMD48; kinase ZAP70; mrtle; mur; Srk; STCD; STD; syk-related protein tyrosine kinase; Syk-related tyrosine kinase; Tyrosine-protein kinase ZAP-70; TZK; ZA70; Zap70; Zap-70; zeta chain of T cell receptor associated protein kinase 70; zeta chain of T cell receptor associated protein kinase 70kDa; zeta-chain (TCR) associated protein kinase; zeta-chain (TCR) associated protein kinase 70; zeta-chain (TCR) associated protein kinase 70kDa; zeta-chain associated protein kinase 70kDa; zeta-chain associated protein kinase, 70kD
Gene Symbols ZAP70
Host Species Rabbit
Immunogen KLH conjugated synthetic phosphopeptide derived from human Zap-70 around the phosphorylation site of Tyr493.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 7535
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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