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Invitrogen™ Phospho-ZEB1 (Ser887) Polyclonal Antibody
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Catalog No. PIPA5105339
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PIPA5105339 100 μL
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Catalog No. PIPA5105339 Supplier Invitrogen™ Supplier No. PA5105339
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of ZEB1 only when phosphorylated at Ser887.

ZEB1 (Zinc finger E-box-binding homeobox 1) acts as a transcriptional repressor. It inhibits interleukin-2 (IL-2) gene expression. ZEB1 enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and depending on the cell type. It represses E-cadherin promoters and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. ZEB1 also represses BCL6 transcription in the presence of the corepressor CTBP1. It postively regulates neuronal differentiation and represses RCOR1 transcription activation during neurogenesis. Mutations in the gene can result in corneal dystrophy, posterior polymorphous and corneal dystrophy, Fuchs endothelial 6.
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Specifications

Antigen Phospho-ZEB1 (Ser887)
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene ZEB1
Gene Accession No. P37275, Q62947, Q64318
Gene Alias [delta]EF1; 3110032K11Rik; AREB6; BZP; Delta EF1; delta-crystallin enhancer binding factor 1; deltaEF1; DELTA-EF1; FECD6; LOW QUALITY PROTEIN: zinc finger E-box-binding homeobox 1; MEB1; MGC133261; Negative regulator of IL2; Nil2; NIL2A; NIL-2A; NIL-2-A; NIL-2-A zinc finger protein; OTTHUMP00000019405; posterior polymorphous corneal dystrophy 3; PPCD3; RP11-472N13.4; Tcf18; TCF8; TCF-8; Transcription factor 8; transcription factor 8 (represses interleukin 2 expression); Tw; twirler; ZEB; Zeb1; Zfhep; Zfhx1a; Zfx1a; Zfx1ha; zinc finger E-box binding homeobox 1; zinc finger E-box-binding homeobox 1; Zinc finger homeobox protein 1a; zinc finger homeodomain enhancer-binding protein
Gene Symbols ZEB1
Host Species Rabbit
Immunogen A synthesized peptide derived from human ZEB1(Accession P37275), corresponding to amino acid residues around phosphorylated Ser887.
Purification Method Sequential Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 21417, 25705, 6935
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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