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PHOX2A/CFEOM2 Rabbit anti-Human, Polyclonal, Bioss
SDP

Catalog No. 501981487
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100 μL
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50-198-1487 100 μL
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Catalog No. 50-198-1487 Supplier Bioss Supplier No. BS11577R
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Description

Rabbit Polyclonal Antibody

PHOX2A and PHOX2B (Paired mesoderm homeobox protein) are closely related, paired-homeodomain transcription factors that function as determinants of the noradrenergic phenotype during embryogenesis. PHOX2 proteins are crucial for the regulation of endogenous hydroxylases in neural crest cells and promote sympathetic neuron generation. Human PHOX2B contains one DNA binding homeobox domain and is required for the differentiation of all central and nonperipheral noradrenergic centers in the brain. In contrast, PHOX2A controls only the differentiation of the main noradrenergic center of the brain. Regulation of PHOX2 may have therapeutic utility in aging or disorders involving degeneration of noradrenergic neurons.

Specifications

Antigen PHOX2A/CFEOM2
Applications Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 μg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene PHOX2A
Gene Accession No. O14813
Gene Alias aristaless homeobox gene homolog; aristaless homeobox homolog; Aristaless homeobox protein homolog; ARIX; arix homeodomain protein; ARIX1 homeodomain protein; CFEOM2; FEOM2; NCAM2; paired like homeobox 2a; paired mesoderm homeobox 2a; Paired mesoderm homeobox protein 2A; Paired-like homeobox 2A; Phox2; PHOX2A; PHOX2A homeodomain protein; Pmx2; PMX2A
Gene Symbols PHOX2A
Host Species Rabbit
Immunogen KLH conjugated synthetic peptide derived from human PHOX2A.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 401
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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