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Invitrogen™ PHOX2A Polyclonal Antibody
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Catalog No. PIPA534381
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100 μg
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Catalog No. Quantity
PIPA534381 100 μg
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Catalog No. PIPA534381 Supplier Invitrogen™ Supplier No. PA534381
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Description

Rabbit Polyclonal Antibody

A suggested positive control is rat brain tissue lysate. PA5-34381 can be used with blocking peptide PEP-1424.

PHOX2A and PHOX2B (Paired mesoderm homeobox protein) are closely related, paired-homeodomain transcription factors that function as determinants of the noradrenergic phenotype during embryogenesis. PHOX2 proteins are crucial for the regulation of endogenous hydroxylases in neural crest cells and promote sympathetic neuron generation. Human PHOX2B contains one DNA binding homeobox domain and is required for the differentiation of all central and nonperipheral noradrenergic centers in the brain. In contrast, PHOX2A controls only the differentiation of the main noradrenergic center of the brain. Regulation of PHOX2 may have therapeutic utility in aging or disorders involving degeneration of noradrenergic neurons.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PHOX2A
Applications Immunohistochemistry, Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene PHOX2A
Gene Accession No. O14813, Q62066, Q62782
Gene Alias aristaless homeobox gene homolog; aristaless homeobox homolog; aristaless homeobox protein homolog; ARIX; arix homeodomain protein; ARIX1 homeodomain protein; CFEOM2; FEOM2; NCAM2; paired like homeobox 2a; paired mesoderm homeobox 2a; paired mesoderm homeobox protein 2A; Paired-like homeobox 2A; Phox2; PHOX2A; PHOX2A homeodomain protein; Pmx2; Pmx2a
Gene Symbols PHOX2A
Host Species Rabbit
Immunogen A 16 amino acid synthetic peptide near the carboxy terminus of human PHOX2A.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 116648, 11859, 401
Target Species Human, Mouse, Rat
Content And Storage Maintain refrigerated at 2°C to 8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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