Invitrogen™ PI3K p85 alpha Monoclonal Antibody (L3-D6)

Catalog No.	Quantity
PIMA534900	100 μL

Catalog No. PIMA534900 Supplier Invitrogen™ Supplier No. MA534900

Description

Mouse Monoclonal Antibody

Positive Control: Raji, U937, HepG2, LOVO, rat brain tissue, human tonsil tissue, human colon cancer tissue, human placenta tissue.

Phosphatidylinositol 3-kinase (PIK3) is a signaling protein that phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position. Signaling is initiated when upstream tyrosine kinase receptors or G protein coupled receptors are bound by their ligands. It binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of insulin, and a mutation in this gene has been associated with insulin resistance. During insulin stimulation, it also binds to IRS-1. Mutations in the gene can result in Agammaglobulinemia 7, SHORT syndrome, or Immunodeficiency 36.

Specifications

• Antigen: PI3K p85 alpha
• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Classification: Monoclonal
• Clone: L3-D6
• Concentration: 2 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol, 0.2% BSA and 0.05% sodium azide; pH 7.4
• Gene: PIK3R1
• Gene Accession No.: P27986
• Gene Alias: AGM7; GRB1; IMD36; p50alpha; p55alpha; p55-GAMMA; p55PIK; p85; p85alpha; p85-ALPHA; phosphatidylinositol 3-kinase; phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma; phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha; Phosphatidylinositol 3-kinase regulatory subunit alpha; phosphatidylinositol 3-kinase regulatory subunit gamma; phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha); phosphatidylinositol 3-kinase-associated p-85 alpha; Phosphoinositide 3-kinase p85 (other splicing variants: p55 and p50); Phosphoinositide 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha); phosphoinositide-3-kinase regulatory subunit; phosphoinositide-3-kinase regulatory subunit 1; phosphoinositide-3-kinase regulatory subunit alpha; phosphoinositide-3-kinase, regulatory subunit 1 (alpha); phosphoinositide-3-kinase, regulatory subunit 1 (p85 alpha); phosphoinositide-3-kinase, regulatory subunit, polypeptide 1 (p85 alpha); PI3K; PI3K regulatory subunit alpha; PI3K regulatory subunit gamma; PI3KA; PI3-kinase p85 subunit alpha; PI3-kinase p85-subunit alpha; PI3-kinase regulatory subunit alpha; PI3-kinase regulatory subunit gamma; PI3-kinase subunit p55-gamma; PI3-kinase subunit p85-alpha; Pik3r1; polypeptide 1 p85 alpha; ptdIns-3-kinase p85-alpha; ptdIns-3-kinase regulatory subunit alpha; PtdIns-3-kinase regulatory subunit p85-al; ptdIns-3-kinase regulatory subunit p85-alpha; RP4-533D7.2
• Gene Symbols: PIK3R1
• Host Species: Mouse
• Immunogen: Recombinant protein within Human PI3-kinase p85 subunit alpha aa 19-219.
• Purification Method: Protein G
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 5295
• Target Species: Human
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles, store in dark
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1