PI3K type IIIRabbit anti-Human, Polyclonal, Rockland™

Catalog No.	Quantity
50-199-2274	100 μg

Catalog No. 50-199-2274 Supplier Rockland Immunochemicals Supplier No. 600401J90

Description

Rabbit Polyclonal Antibody

Store vial at -20°C prior to opening. Aliquot contents and freeze at -20°C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. A BLAST analysis was used to suggest cross-reactivity with mouse and human based on 100% sequence homology. Cross-reactivity with PI3K, type III from other sources has not been determined.

PIKFYVE belongs to a large family of lipid kinases that alter the phosphorylation status of intracellular phosphatidylinositol. The content of phosphatidylinositol 3,5-bisphosphateP2) in endosomal membranes changes dynamically with fission and fusion events that generate or absorb intracellular transport vesicles. PIKFYVE is the PtdIns(3,5)P2-producing component of a trimolecular complex that tightly regulates the level of PtdIns(3,5)P2. Other components of this complex are the PIKFYVE activator VAC14 and the PtdIns(3,5)P2 phosphatase FIG4. In addition to its phosphoinositide 5-kinase activity, PIKFYVE also has protein kinase activity. For a review, see Shisheva.

Specifications

• Antigen: PI3K type III
• Applications: ELISA, Immunoprecipitation, Western Blot
• Classification: Polyclonal
• Concentration: 1.02 mg/mL
• Conjugate: Unconjugated
• Formulation: 0.02M potassium phosphate with 0.15M NaCl, 50% glycerol and no preservative; pH 7.2
• Gene: PIKFYVE
• Gene Accession No.: Q9Y2I7
• Gene Alias: 1-phosphatidylinositol 3-phosphate 5-kinase; 1-phosphatidylinositol-3-phosphate 5-kinase; 5230400C17Rik; CFD; epididymis luminal protein 37; FAB1; FYVE finger-containing phosphoinositide kinase; HEL37; Kiaa0981; p235; Phosphatidylinositol 3-phosphate 5-kinase; Phosphatidylinositol 3-phosphate 5-kinase type III; phosphatidylinositol-3-phosphate 5-kinase type III; phosphatidylinositol-3-phosphate/phosphatidylinositol 5-kinase, type III; phosphatidylinositol-4-phosphate 5-kinase, type III; phosphoinositide kinase, FYVE finger containing; phosphoinositide kinase, FYVE-type zinc finger containing; PIKFYVE; Pip5k; PIP5K3; Pipk5k3; PipkIII; PIPkin-III; PtdIns(4)P-5-kinase; type III PIP kinase; ZFYVE29; zinc finger, FYVE domain containing 29
• Gene Symbols: PIKFYVE
• Host Species: Rabbit
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 200576
• Target Species: Human
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid