Invitrogen™ PI4K2A Monoclonal Antibody (3E1)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA522144

Catalog No. PIMA522144

Description

Peptide Sequence: LILPKISDPN FVKDLEEDLY ELFKKDPGFD RGQFHKQIAV MRGQILNLTQ ALKDNKSPLH LVQMPPVIVE TARSHQRSSS ESYTQSFQSR KPFFS.

PI4K2A (PI4K2 alpha) lipid kinase or phosphatidylinositol 4-kinase type 2 alpha is involved in the formation of phosphatidylinositolpolyphosphates (PtdInsPs) which are centrally involved in many biologic processes ranging from cell growth and organization of the actin cytoskeleton to endo- and exocytosis. PI4K2A phosphorylates PtdIns at the D-4 position which is an essential step in the biosynthesis of PtdInsPs. PI4K2A is a novel regulator of tumor growth by its action on angiogenesis and HIF-1alpha regulation. PI4K2A generates PtdIns4P-rich domains within the Golgi which regulate targeting of clathrin adaptor AP-1 complexes. PI4K2A is also required for Wnt to regulate LRP6 phosphorylation.

Specifications

• Antigen: PI4K2A
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with no preservative; pH 7.4
• Gene Accession No.: Q9BTU6
• Gene Symbols: Pi4k2a
• Immunogen: PI4K2A (NP_060895.1, 383 a.a. ~ 477 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2b κ

• Applications: ELISA
• Clone: 3E1
• Conjugate: Unconjugated
• Gene: Pi4k2a
• Gene Alias: 55 kDa type II phosphatidylinositol 4-kinase; null; phosphatidylinositol 4-kinase; phosphatidylinositol 4-kinase type 2 alpha; phosphatidylinositol 4-kinase type 2-alpha; phosphatidylinositol 4-kinase type II; phosphatidylinositol 4-kinase type II (PI4KII); phosphatidylinositol 4-kinase type II-alpha; Pi4k2; PI4K2A; Pi4kii; PIK42A
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 55361
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid