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Invitrogen™ PI4K2A Monoclonal Antibody (3E1)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA522144

Catalog No. PIMA522144


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Description

Description

Peptide Sequence: LILPKISDPN FVKDLEEDLY ELFKKDPGFD RGQFHKQIAV MRGQILNLTQ ALKDNKSPLH LVQMPPVIVE TARSHQRSSS ESYTQSFQSR KPFFS.

PI4K2A (PI4K2 alpha) lipid kinase or phosphatidylinositol 4-kinase type 2 alpha is involved in the formation of phosphatidylinositolpolyphosphates (PtdInsPs) which are centrally involved in many biologic processes ranging from cell growth and organization of the actin cytoskeleton to endo- and exocytosis. PI4K2A phosphorylates PtdIns at the D-4 position which is an essential step in the biosynthesis of PtdInsPs. PI4K2A is a novel regulator of tumor growth by its action on angiogenesis and HIF-1alpha regulation. PI4K2A generates PtdIns4P-rich domains within the Golgi which regulate targeting of clathrin adaptor AP-1 complexes. PI4K2A is also required for Wnt to regulate LRP6 phosphorylation.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

PI4K2A
Monoclonal
1 mg/mL
PBS with no preservative; pH 7.4
Q9BTU6
Pi4k2a
PI4K2A (NP_060895.1, 383 a.a. ~ 477 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
100 μg
Primary
Human
Antibody
IgG2b κ
ELISA
3E1
Unconjugated
Pi4k2a
55 kDa type II phosphatidylinositol 4-kinase; null; phosphatidylinositol 4-kinase; phosphatidylinositol 4-kinase type 2 alpha; phosphatidylinositol 4-kinase type 2-alpha; phosphatidylinositol 4-kinase type II; phosphatidylinositol 4-kinase type II (PI4KII); phosphatidylinositol 4-kinase type II-alpha; Pi4k2; PI4K2A; Pi4kii; PIK42A
Mouse
Affinity Chromatography
RUO
55361
-20°C, Avoid Freeze/Thaw Cycles
Liquid
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