Invitrogen™ PI4K2B Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA130306

Catalog No. PIPA130306

Description

Recommended positive controls: Mouse brain and Saos 2 cell lysate.

PI4K2B lipid kinase is a member of the phosphatidylinositol 4-kinase family (PI4K) that phosphorylate phosphatidylinositol to generate phosphatidylinositol 4-phosphate which are immediate precursor of several important signaling and scaffolding molecules. PI4K2B is primarily a cytosolic PI4K that is recruited to membranes where it stimulates phosphatidylinositol 4,5-bisphosphate syntheses. PI4K2B uses phosphatidylinositol as its primary substrate and has no activity on phosphatidylinositol monophosphates. PI4K2B is a restricted minor histocompatibility antigen in patients that had been successfully treated with donor lymphocyte infusions for relapsed chronic myeloid leukemia after allogeneic stem cell transplantation. Phosphatidylinositol 4-kinases (PI4Ks) phosphorylate phosphatidylinositol to generate phosphatidylinositol 4-phosphate (PIP), an immediate precursor of several important signaling and scaffolding molecules. PIP itself may also have direct functional and structural roles. PI4K2B is a primarily cytosolic PI4K that is recruited to membranes, where it stimulates phosphatidylinositol 4, 5-bisphosphate synthesis (Wei et al., 2002 ).

Specifications

• Antigen: PI4K2B
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PI4K2B
• Gene Alias: 2610042N09Rik; 4933409G22Rik; hypothetical protein; phosphatidylinositol 4-kinase; phosphatidylinositol 4-kinase type 2 beta; Phosphatidylinositol 4-kinase type 2 beta; Phosphatidylinositol 4-kinase type 2-beta; phosphatidylinositol 4-kinase type 2-beta; Phosphatidylinositol 4-kinase type II-beta; phosphatidylinositol 4-kinase type-II beta; PI4K2B; PI4K2B protein; PI4KIIB; PI4KII-BETA; PIK42B; RCJMB04_25j21
• Host Species: Rabbit
• Purification Method: Ammonium sulfate precipitation, Size-exclusion - Dialysis
• Regulatory Status: RUO
• Gene ID (Entrez): 55300, 67073
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.3 mg/mL
• Formulation: PBS with 0.09% sodium azide
• Gene Accession No.: Q8CBQ5, Q8TCG2
• Gene Symbols: PI4K2B
• Immunogen: KLH conjugated synthetic peptide between 305-336 amino acids from the C-terminal region of human PI4K2B.
• Quantity: 400 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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