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Invitrogen™ PIAS3 Polyclonal Antibody
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Catalog No. PIPA552288
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100 μL
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PIPA552288 100 μL
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Catalog No. PIPA552288 Supplier Invitrogen™ Supplier No. PA552288
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: PTKKHCSVTS AAIPALPGSK GVLTSGHQPS SVLRSPAMGT LGGDFLSSLP LHEYPPAFPL GADIQGLDLF SFLQTESQHY GPSVITSLDE QDALGHFFQY RGTPSHFLGP LAPTLGSSHC SATPAPPPGR VSSIVAPG Highest antigen sequence identity to the following orthologs: Mouse - 96%, Rat - 93%.

The PIAS (protein inhibitor of activated STAT) proteins play a crucial role as transcriptional coregulators in various cellular pathways, including the STAT, p53 and the steroid hormone signaling pathway. The PIAS protein family includes at least five evolutionarily conserved genes, including PIAS3. The major function of the PIAS proteins is the control of gene transcription and can also act as small ubiquitin-like-modifier (SUMO) E3 ligases. PIAS3 binds specifically to STAT3 following the stimulation of STAT3. Increased expression of PIAS3 has been observed in several human cancers, including lung, breast, and brain tumors, but not in anaplastic lymphoma kinase-positive T/null-cell lymphomas, indicating that PIAS3 plays multiple roles in different tissue and cell types.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PIAS3
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene PIAS3
Gene Accession No. Q9Y6X2
Gene Alias E3 SUMO-protein ligase PIAS3; E3 SUMO-protein transferase PIAS3; KChAP; PIAS3; Pias3l; potassium channel regulatory protein KChAP; potassium channel-associated protein; protein inhibitor of activated STAT 3; protein inhibitor of activated STAT protein 3; protein inhibitor of activated STAT, 3; zinc finger, MIZ-type containing 5; ZMIZ5
Gene Symbols PIAS3
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human PIAS3. Recombinant protein control fragment (Product #RP-104011).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 10401
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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