Invitrogen™ PIAS3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA589212

Catalog No. PIPA589212

Description

Immunogen sequence: FMEDGSWCPM KPKKEASEVC PPPGYGLDGL QYSPVQGGDP SENKKKVEVI DLTIESSSDE EDLPPTKKHC SVTSAAIPAL PGSKGVLTSG HQPSSVLRSP AMGTLGGDFL SSLPLHEYPP AFPLGADIQG LDLFSFLQTE SQHYGPSVIT SLDEQDALGH FFQYRGTPSH FLGPLAPTLG SSHCSATPAP PPGRVSSIVA PGGALREGHG GPLPSGPSLT GCRSDIISLD.

The PIAS (protein inhibitor of activated STAT) proteins play a crucial role as transcriptional coregulators in various cellular pathways, including the STAT, p53 and the steroid hormone signaling pathway. The PIAS protein family includes at least five evolutionarily conserved genes, including PIAS3. The major function of the PIAS proteins is the control of gene transcription and can also act as small ubiquitin-like-modifier (SUMO) E3 ligases. PIAS3 binds specifically to STAT3 following the stimulation of STAT3. Increased expression of PIAS3 has been observed in several human cancers, including lung, breast, and brain tumors, but not in anaplastic lymphoma kinase-positive T/null-cell lymphomas, indicating that PIAS3 plays multiple roles in different tissue and cell types.

Specifications

• Antigen: PIAS3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PIAS3
• Gene Alias: E3 SUMO-protein ligase PIAS3; E3 SUMO-protein transferase PIAS3; KChAP; PIAS3; Pias3l; potassium channel regulatory protein KChAP; potassium channel-associated protein; protein inhibitor of activated STAT 3; protein inhibitor of activated STAT protein 3; protein inhibitor of activated STAT, 3; zinc finger, MIZ-type containing 5; ZMIZ5
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 10401
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Immunocytochemistry
• Concentration: 4.39 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q9Y6X2
• Gene Symbols: PIAS3
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 399-628 of human PIAS3 (NP_0060902).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG