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PICALM/CALM Rabbit anti-Human, Polyclonal, Bioss
SDP

Catalog No. 501981565
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100 μL
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50-198-1565 100 μL
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Catalog No. 50-198-1565 Supplier Bioss Supplier No. BS11665R
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Description

Rabbit Polyclonal Antibody

PICALM, also known as the clathrin assembly lymphoid myeloid leukemia (CALM) protein, co-localizes with clathrin at clathrin-coated areas of the plasma membrane and in the Golgi area, and is thought to be an important component of the coated pit internalization machinery. Fusion proteins involving PICALM have been implicated in acute myeloid and T-cell acute lymphoblastic leukemia. PICALM is also expressed in neurons and is present at the synapse where it facilitates the endocytosis of the synaptic vesicle protein VAMP2. Recent studies have identified variants of PICALM associated with Alzheimer′s disease and have suggested this protein may play a role in the endocytosis and recycling of the amyloid protein precursor (APP).

Specifications

Antigen PICALM/CALM
Applications Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 μg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene Picalm
Gene Accession No. Q13492
Gene Alias CALM; Clathrin assembly lymphoid myeloid leukemia; Clathrin assembly lymphoid myeloid leukemia protein; clathrin-assembly lymphoid leukemia protein; clathrin-assembly lymphoid myeloid leukemia protein; CLTH; Fit1; fit-1; LAP; mKIAA4114; PAP180; phosphatidylinositol binding clathrin assembly protein; Phosphatidylinositol-binding clathrin assembly protein; PICALM; rCALM
Gene Symbols Picalm
Host Species Rabbit
Immunogen KLH conjugated synthetic peptide derived from human PICALM/CALM.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 8301
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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