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Invitrogen™ PICK1 Polyclonal Antibody
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Catalog No. PIPA5119691
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100 μL
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PIPA5119691 100 μL
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Catalog No. PIPA5119691 Supplier Invitrogen™ Supplier No. PA5119691
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Description

Rabbit Polyclonal Antibody

Positive Control: SH-SY5Y cell lysate, 293 cell lysate, F9, MCF-7, rat brain tissue, human colon tissue, mouse brain tissue, SH-SY5Y. Subcellular Location: Cytoskeleton, perinuclear region, membrane, postsynaptic density, synaptosome.

PSD-95/DLG/ZO-1 (PDZ) domain-containing proteins play a central role in synaptic membrane protein localization. The protein interacting with protein kinase C (PICK1) is a synaptic PDZ domain protein that also contains a coiled-coil and acidic domain. Studies indicate that PICK1 functions as a targeting and transport protein and has been shown to interact with protein kinase C alpha (PKCalpha), AMPA-type glutamate receptors, and several other membrane receptors via its PDZ domain. The interaction of PICK1 with PKCalpha is highly dependent on the activation of the kinase. It appears that PICK1 directs the activated form of PKCalpha to membrane anchored GluR2. Once phosphorylated by PKCalpha, GluR2 is released from the synaptic anchor proteins. Once released, GluR2 is transported from the synaptic membrane in a PICK1-dependent manner.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PICK1
Applications Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation TBS with 0.2% BSA, 50% glycerol and 0.05% sodium azide; pH 7.4
Gene Pick1
Gene Accession No. Q62083, Q9EP80, Q9NRD5
Gene Alias MGC15204; OTTHUMP00000028509; PICK; Pick1; PRKCA-binding protein; Prkcabp; Protein interacting with C kinase 1; protein interacting with PRKCA 1; protein kinase C, alpha binding protein; protein kinase C-alpha-binding protein; protein that interacts with C kinase 1
Gene Symbols Pick1
Host Species Rabbit
Immunogen Synthetic peptide within rat PICK1 aa 280-330.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 18693, 84591, 9463
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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