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Invitrogen™ PICK1 Polyclonal Antibody
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Catalog No. PIPA518593
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100 μg
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Catalog No. Quantity
PIPA518593 100 μg
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Catalog No. PIPA518593 Supplier Invitrogen™ Supplier No. PA518593
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Description

Goat Polyclonal Antibody

This antibody is predicted to react with bovine, canine, human and porcine based on sequence homology. This antibody is tested in Peptide ELISA: antibody detection limit dilution 16,000.

PSD-95/DLG/ZO-1 (PDZ) domain-containing proteins play a central role in synaptic membrane protein localization. The protein interacting with protein kinase C (PICK1) is a synaptic PDZ domain protein that also contains a coiled-coil and acidic domain. Studies indicate that PICK1 functions as a targeting and transport protein and has been shown to interact with protein kinase C alpha (PKCalpha), AMPA-type glutamate receptors, and several other membrane receptors via its PDZ domain. The interaction of PICK1 with PKCalpha is highly dependent on the activation of the kinase. It appears that PICK1 directs the activated form of PKCalpha to membrane anchored GluR2. Once phosphorylated by PKCalpha, GluR2 is released from the synaptic anchor proteins. Once released, GluR2 is transported from the synaptic membrane in a PICK1-dependent manner.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PICK1
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
Gene Pick1
Gene Accession No. Q62083, Q9NRD5
Gene Alias MGC15204; OTTHUMP00000028509; PICK; Pick1; PRKCA-binding protein; Prkcabp; Protein interacting with C kinase 1; protein interacting with PRKCA 1; protein kinase C, alpha binding protein; protein kinase C-alpha-binding protein; protein that interacts with C kinase 1
Gene Symbols Pick1
Host Species Goat
Immunogen Synthetic peptide sequence (HYNKLQADPKQ) corresponding to the internal amino acids of PICK1 (aa 100-110).
Purification Method Ammonium sulfate precipitation
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 18693, 9463
Target Species Human, Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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