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Invitrogen™ PICK1 Polyclonal Antibody
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Catalog No. PIPA567255
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PIPA567255 100 μL
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Catalog No. PIPA567255 Supplier Invitrogen™ Supplier No. PA567255
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: IEEDKLGIPTV PGKVTLQKDA QNLIGISIGG GAQYCPCLYI VQVFDNTPAA LDGTVAAGDE ITGVNGRSIK GKTKVEVAKM IQEVKGEVTI HYNKLQADPK QGMSLDIVLK KVKHRLVENM SSGTADALGL SRAILCNDGL VKRLEELERT A Highest antigen sequence identity to the following orthologs - mouse 99%, rat 100%.

PSD-95/DLG/ZO-1 (PDZ) domain-containing proteins play a central role in synaptic membrane protein localization. The protein interacting with protein kinase C (PICK1) is a synaptic PDZ domain protein that also contains a coiled-coil and acidic domain. Studies indicate that PICK1 functions as a targeting and transport protein and has been shown to interact with protein kinase C alpha (PKCalpha), AMPA-type glutamate receptors, and several other membrane receptors via its PDZ domain. The interaction of PICK1 with PKCalpha is highly dependent on the activation of the kinase. It appears that PICK1 directs the activated form of PKCalpha to membrane anchored GluR2. Once phosphorylated by PKCalpha, GluR2 is released from the synaptic anchor proteins. Once released, GluR2 is transported from the synaptic membrane in a PICK1-dependent manner.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PICK1
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Pick1
Gene Accession No. Q9NRD5
Gene Alias MGC15204; OTTHUMP00000028509; PICK; Pick1; PRKCA-binding protein; Prkcabp; Protein interacting with C kinase 1; protein interacting with PRKCA 1; protein kinase C, alpha binding protein; protein kinase C-alpha-binding protein; protein that interacts with C kinase 1
Gene Symbols Pick1
Host Species Rabbit
Immunogen Recombinant Human PICK1. Recombinant protein control fragment (Product #RP-105571).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 9463
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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