PICK1 Rabbit anti-Human, Clone: 4G1, Bioss

Catalog No.	Quantity
50-198-9739	100 μL

Catalog No. 50-198-9739 Supplier Bioss Supplier No. BSM54393R

Description

Rabbit Monoclonal Antibody

PSD-95/DLG/ZO-1 (PDZ) domain-containing proteins play a central role in synaptic membrane protein localization. The protein interacting with protein kinase C (PICK1) is a synaptic PDZ domain protein that also contains a coiled-coil and acidic domain. Studies indicate that PICK1 functions as a targeting and transport protein and has been shown to interact with protein kinase C alpha (PKCalpha), AMPA-type glutamate receptors, and several other membrane receptors via its PDZ domain. The interaction of PICK1 with PKCalpha is highly dependent on the activation of the kinase. It appears that PICK1 directs the activated form of PKCalpha to membrane anchored GluR2. Once phosphorylated by PKCalpha, GluR2 is released from the synaptic anchor proteins. Once released, GluR2 is transported from the synaptic membrane in a PICK1-dependent manner.

Specifications

• Antigen: PICK1
• Applications: Flow Cytometry, Immunoprecipitation, Western Blot
• Classification: Monoclonal
• Clone: 4G1
• Concentration: 1 μg/mL
• Conjugate: Unconjugated
• Formulation: TBS with 1% BSA, 40% glycerol and 0.05% sodium azide; pH
• Gene: Pick1
• Gene Accession No.: Q9NRD5
• Gene Alias: MGC15204; OTTHUMP00000028509; PICK; Pick1; PRKCA-binding protein; PRKCABP; Protein interacting with C kinase 1; protein interacting with PRKCA 1; protein kinase C, alpha binding protein; Protein kinase C-alpha-binding protein; protein that interacts with C kinase 1
• Gene Symbols: Pick1
• Host Species: Rabbit
• Immunogen: Recombinant protein within N-terminal human PICK1.
• Purification Method: Protein A
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 9463
• Target Species: Human
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG