Invitrogen™ PICK1 Recombinant Rabbit Monoclonal Antibody (JG30-80)

Rabbit Recombinant Monoclonal Antibody

Supplier:  Invitrogen™ MA534772

Catalog No. PIMA534772

Description

Positive Control: SK-Br-3, 293T.

PSD-95/DLG/ZO-1 (PDZ) domain-containing proteins play a central role in synaptic membrane protein localization. The protein interacting with protein kinase C (PICK1) is a synaptic PDZ domain protein that also contains a coiled-coil and acidic domain. Studies indicate that PICK1 functions as a targeting and transport protein and has been shown to interact with protein kinase C alpha (PKCalpha), AMPA-type glutamate receptors, and several other membrane receptors via its PDZ domain. The interaction of PICK1 with PKCalpha is highly dependent on the activation of the kinase. It appears that PICK1 directs the activated form of PKCalpha to membrane anchored GluR2. Once phosphorylated by PKCalpha, GluR2 is released from the synaptic anchor proteins. Once released, GluR2 is transported from the synaptic membrane in a PICK1-dependent manner.

Specifications

• Antigen: PICK1
• Classification: Recombinant Monoclonal
• Concentration: 1 mg/mL
• Formulation: TBS with 0.05% BSA, 40% glycerol and 0.05% sodium azide; pH 7.4
• Gene Accession No.: Q9NRD5
• Gene Symbols: Pick1
• Immunogen: Synthetic peptide within Human PICK1 aa 1-50.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

• Applications: Flow Cytometry, Immunoprecipitation, Western Blot
• Clone: JG30-80
• Conjugate: Unconjugated
• Gene: Pick1
• Gene Alias: MGC15204; OTTHUMP00000028509; PICK; Pick1; PRKCA-binding protein; Prkcabp; Protein interacting with C kinase 1; protein interacting with PRKCA 1; protein kinase C, alpha binding protein; protein kinase C-alpha-binding protein; protein that interacts with C kinase 1
• Host Species: Rabbit
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 9463
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles, store in dark
• Form: Liquid