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Thermo Scientific™ Pierce™ SMCC

Catalog No. PI22360
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50 mg
10 x 1 mg
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Catalog No. Quantity
PI22360 50 mg
PIA35394 10 x 1 mg
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Catalog No. PI22360 Supplier Thermo Scientific™ Supplier No. 22360
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Description

No-Weigh™ Format

Thermo Scientific™ Pierce SMCC is an amine-to-sulfhydryl crosslinker that contains NHS-ester and maleimide reactive groups at opposite ends of a medium-length cyclohexane-stabilized spacer arm (8.3 Ås).

Highlights:

  • Cyclohexane bridge adds stability to the maleimide-reactive group; N-(4-carboxycyclohexylmethyl) maleimide groups are stable for 64 hours in 0.1 M sodium phosphate buffer, pH 7.0 at 4°C
  • Ideal for coupling enzymes to antibodies
  • Reactive groups: NHS-ester and maleimide
  • Reactive toward: amino and sulfhydryl groups
TRUSTED_SUSTAINABILITY

Specifications

Chemical Reactivity Amine-Sulfhydryl
Cleavable By Thiols
Molecular Weight (g/mol) 334.32
PEGylated No
Spacer Arm Length 8.3 Å
Content And Storage Upon receipt store desiccated at 4°C.
Cell Permeability Yes
Shipping Condition Ambient
Product Line Pierce
Labeling Method Chemical Labeling
Crosslinker Type Heterobifunctional
Reactive Moiety Maleimide, NHS Ester
Spacer Short (<10 Å)
Form Powder
Quantity 50 mg
Solubility DMF, DMSO
Format Standard, Single-use
Water Soluble No
Product Type Crosslinker
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Frequently Asked Questions (FAQs)

Can you provide the shelf-life for SMCC (succinimidyl 4-(N-maleimidomethyl)cyclohexane-1-carboxylate)?

SMCC (succinimidyl 4-(N-maleimidomethyl)cyclohexane-1-carboxylate) is covered under our general 1-year warranty and is guaranteed to be fully functional for 12 months from the date of shipment, if stored as recommended. Please see section 8.1 of our Terms & Conditions of Sale (https://www.thermofisher.com/content/dam/LifeTech/Documents/PDFs/Terms-and-Conditions-of-Sale.pdf) for more details.
What is the difference between SMCC and Sulfo-SMCC?

SMCC is an amine-to-sulfhydryl crosslinker that contains NHS-ester and maleimide reactive groups at opposite ends of a medium-length cyclohexane-stabilized spacer arm (8.3 angstroms). Sulfo-SMCC is a similar compound but it has a sulfonate group on the NHS ring which makes it water-soluble whereas SMCC is water-insoluble and needs to be dissolved first in an organic solvent like DMF or DMSO. Subsequent dilution into aqueous reaction buffer is generally possible, and most protein reactants will remain soluble if the final concentration of organic solvent is less than 10%.

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov

For Research Use Only. Not for use in diagnostic procedures.

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