Invitrogen™ PIEZO1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA572973

Catalog No. PIPA572973

Description

PIEZO1 Polyclonal Antibody for Western Blot, ICC/IF, IHC (P), Flow

Piezo1 is a pore-forming subunit of a mechanosensitive non-specific cation channel, and generates currents characterized by a linear current-voltage relationship that are sensitive to ruthenium red and gadolinium. Structurally, Piezo1 contains 36 transmembrane domains and functions as a homotetramer. Piezo1 plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling. In the kidney, Piezo1 may contribute to the detection of intraluminal pressure changes and to urine flow sensing. Piezo1 acts as shear-stress sensor that promotes endothelial cell organization and alignment in the direction of blood flow through calpain activation and plays a key role in blood vessel formation and vascular structure in both development and adult physiology. The protein encoded by the Piezo1 gene is a mechanically-activated ion channel that links mechanical forces to biological signals. Defects in this gene have been associated with dehydrated hereditary stomatocytosis. Diseases associated with PIEZO1 include Dehydrated Hereditary Stomatocytosis with/without Pseudohyperkalemia And/Or Perinatal Edema and Lymphedema.

Specifications

• Antigen: PIEZO1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Piezo1
• Gene Alias: 9630020g22; DHS; Fam38a; family with sequence similarity 38, member A; KIAA0233; LMPH3; Membrane protein induced by beta-amyloid treatment; Mib; mKIAA0233; piezo type mechanosensitive ion channel component 1; Piezo1; piezo-type mechanosensitive ion channel component 1; Protein FAM38A; protein PIEZO1
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 100733448, 234839, 9780
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: E2JF22, Q92508
• Gene Symbols: Piezo1
• Immunogen: A synthetic peptide made to an internal portion of the human PIEZO1 protein (between residues 950-1000) [UniProt Q92508].
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Guinea Pig
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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