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Invitrogen™ PIF1 Polyclonal Antibody
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Catalog No. PIPA5103641
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PIPA5103641 100 μL
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Catalog No. PIPA5103641 Supplier Invitrogen™ Supplier No. PA5103641
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total PIF1.

PIF1 is a single-stranded (ss) DNA-dependent ATPase as well as a DNA helicase that unwinds DNA in a 5' to 3' direction with respect to the DNA strand on which it binds first. This protein is critical to DNA replication and telomere length maintenance in Saccharomyces cerevisiae. The PIF1 gene is highly conserved from yeast to humans. Mutations in the gene that encodes for PIF1 cause all telomeres to lengthen, suggesting that the PIF1 functions as a catalytic inhibitor of both new telomere formation and telomere elongation. Human PIF1 preferentially binds telomeric DNA where it inhibits telomerase activity. PIF1 specifically counteracts the RecQ homolog Sgs1 helicase activity, and degradation of PIF1 is mediated by the ubiquitin-26S proteasome pathway.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PIF1
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene PIF1
Gene Accession No. Q1HG60, Q80SX8, Q9H611
Gene Alias 4631410M14; AI449441; ATP-dependent DNA helicase PIF1; ATP-dependent DNA helicase PIF1 {ECO:0000255; C15orf20; DNA helicase-like protein; DNA repair and recombination helicase PIF1; DNA repair and recombination helicase PIF1 {ECO:0000255; HAMAP-Rule:MF_03176}; petite integration frequency 1; PIF; Pif1; PIF1 5'-to-3' DNA helicase; PIF1 5'-to-3' DNA helicase homolog; PIF1 5'-to-3' DNA helicase homolog (S. cerevisiae); PIF1 homolog; Pif1/Rrm3 DNA helicase-like protein; Pif1/Rrm3 DNA-helicase-like protein
Gene Symbols PIF1
Host Species Rabbit
Immunogen A synthesized peptide derived from human PIF1(Accession Q9H611), corresponding to amino acid residues V322-V372.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 208084, 367645, 80119
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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