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  5. Tocris Bioscience™ Pifithrin-μ

Tocris Bioscience™ Pifithrin-μ
SDP

Catalog No. 265350 Shop All Novus Biologicals Products
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Catalog No. Quantity
26-535-0 50 mg
26-531-0 10 mg
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Catalog No. 26-535-0 Supplier Tocris Bioscience™ Supplier No. 2653/50
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Description

Inhibitor of p53-mitochondrial binding

Pifithrin-μ inhibits p53 binding to mitochondria by reducing its affinity for antiapoptotic proteins Bcl-2 and Bcl-XL. Displays no effect on the transactivational or cell cycle checkpoint control function of p53. Potentially increases reprogramming efficiency of human somatic cells to induced pluripotent stem cells (iPSCs) by silencing p53. Pifithrin-μ reduces cell death induced by γ-radiation in vitro and protects mice from doses of radiation that cause lethal hematopoietic syndrome. Selectively inhibits heat shock protein 70 (HSP70) activity.

Chemical Identifiers

CAS 64984-31-2
Molecular Formula C8H7NO2S

Specifications

Quantity 50 mg
Formula Weight 181.21
Purity >99%
Molecular Weight (g/mol) 181.209
Chemical Name or Material Pifithrin-μ

Safety and Handling

Recommended Storage Store at +4°C
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