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Tocris Bioscience™ PIK 90
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Catalog No. 790210
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10 mg
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79-021-0 10 mg
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Catalog No. 79-021-0 Supplier Tocris Bioscience™ Supplier No. 7902/10
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Description

Potent PI3K inhibitor, also used in hPSCs mesendoderm differentiation

PIK 90 is a potent inhibitor of PI 3-K α/γ/δ kinases (IC50 = 11, 18, 47, 58 and 64 nM against p110α, p110γ, PI 3-KC2α, p110δ and PI 3-KC2α, respectively) as well as PIKKs (IC50 = 13 nM against DNA-PK). It inhibits the fMLP-stimulated phosphorylation of Akt and impairs polarity and chemotaxis in dHL60 cells. It suppresses insulin-stimulated phosphorylation of Akt and rpS6 in 3T3-L1 adipocytes and L6 myotubes in vitro and prevents insulin-induced blood glucose reduction in mice in vivo. PIK 90 can be used in combination with other small molecules and proteins for mesendoderm induction in protocols to differentiate iPSCs into organ-specific mesenchyme.

Specifications

Chemical Name or Material N-(2,3-Dihydro-7,8-dimethoxyimidazo[1,2-c]quinazolin-5-yl)-3-pyridinecarboxamide
CAS 677338-12-4
Quantity 10 mg
Target PI 3-Kinase Inhibitors
Molecular Formula C18H17N5O3
Purity 0.98
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