Invitrogen™ PIK3C2B Polyclonal Antibody

Catalog No.	Quantity
PIPA565614	100 μL

Catalog No. PIPA565614 Supplier Invitrogen™ Supplier No. PA565614

Description

Rabbit Polyclonal Antibody

Immunogen sequence: PHTVANGHELF EVSEERDEEV AAFCHMLDIL RSGSDIQDYF LTGYVWSAVT PSPEHLGDEV NLKVTVLCDR LQEALTFTCN CSSTVDLLIY QTLCY Highest antigen sequence identity to the following orthologs - mouse 92%, rat 90%.

The Class II PI3 kinases, including PIK3C2B, phosphorylate the 3 position of PI or PI4P. Though not as well studied as the class I PI3 kinases, the class II enyzmes have been linked to diverse, receptor-mediated cellular processes including insulin signaling, neuronal survival, and growth factor signaling. Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains.

Specifications

• Antigen: PIK3C2B
• Applications: Immunocytochemistry
• Classification: Polyclonal
• Concentration: 0.05 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene: PIK3C2B
• Gene Accession No.: O00750
• Gene Alias: C2-PI3K; C330011J12Rik; Gm199; phosphatidylinositol 3-kinase C2 domain-containing beta polypeptide; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta; phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit beta; phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta; phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta; phosphoinositide 3-kinase-C2-beta; phosphoinositide-3-kinase, class 2, beta polypeptide; pi3kc2b; PI3KC2beta; PI3K-C2beta; PI3K-C2-beta; PIK3C2B; PTDINS-3-kinase C2 beta; ptdIns-3-kinase C2 subunit beta
• Gene Symbols: PIK3C2B
• Host Species: Rabbit
• Immunogen: Recombinant Human PIK3C2B. Recombinant protein control fragment (Product #RP-106280).
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 5287
• Target Species: Human
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG